Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.47 |
| ▸ | CDK2 | P24941 | 10/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 4/20 | 0.37 |
| ▸ | NPR1 | P16066 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.35 |
| ▸ | CCNH | P51946 | 3/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444082 | 0.88 | CDK1 (0.47) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3446443 | 0.87 | CDK1 (0.45) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3445260 | 0.86 | CDK1 (0.49) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3444254 | 0.86 | CDK1 (0.47) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3444706 | 0.84 | STAT3 (0.42) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3445132 | 0.84 | STAT3 (0.41) | CDK1CDK2STAT3CCNE1CDK5 | |
| SCHEMBL3444871 | 0.82 | CDK1 (0.45) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3444278 | 0.79 | CDK2 (0.45) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL3444723 | 0.79 | CDK1 (0.47) | CDK1CDK2CCNB1CCNB2CCNB3 | |
| SCHEMBL6203806 | 0.78 | STAT3 (0.36) | CDK1CDK2CCNB1CCNB2CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | claimed |
| US-20060035909-A1 | 2,6,9-trisubstituted 8-azapurines such as 2-(4-aminocyclohexylamino)-6-benzylamino-9-isopropyl-8-azapurine, used as cyclin-dependent kinase inhibitors, in the treatment of skin disorders, viral infections, cancer, arthritis, lupus, diabetes, multiple sclerosis, restenosis, polycystic kidney disease, gout | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2006-02-16 | — | — | US | claimed |
| US-7816350-B2 | Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2010-10-19 | — | — | US | disclosed |
| US-20060035909-A1 | 2,6,9-trisubstituted 8-azapurines such as 2-(4-aminocyclohexylamino)-6-benzylamino-9-isopropyl-8-azapurine, used as cyclin-dependent kinase inhibitors, in the treatment of skin disorders, viral infections, cancer, arthritis, lupus, diabetes, multiple sclerosis, restenosis, polycystic kidney disease, gout | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035909-A1 | 2,6,9-trisubstituted 8-azapurines such as 2-(4-aminocyclohexylamino)-6-benzylamino-9-isopropyl-8-azapurine, used as cyclin-dependent kinase inhibitors, in the treatment of skin disorders, viral infections, cancer, arthritis, lupus, diabetes, multiple sclerosis, restenosis, polycystic kidney disease, gout | CDK8, CDK6, CDK1 | CDK1 3/4885CDK2 13/4885CCNB1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.