SCHEMBL3445313

SCHEMBL3445313

CCC(CO)Nc1nc(NCc2ccccc2)c2nnn(C)c2n1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 9/20 0.71
CCNA2 P20248 4/20 0.71
CCNA1 P78396 4/20 0.71
CACNA1B Q00975 2/20 0.68
CDK1 P06493 15/20 0.66
CDK5 Q00535 9/20 0.66
CDK7 P50613 6/20 0.66
CDK9 P50750 5/20 0.66
CCNE1 P24864 5/20 0.66
CCNH P51946 4/20 0.66
CCNT1 O60563 3/20 0.66
CDK5R1 Q15078 3/20 0.66
CCNB1 P14635 3/20 0.66
CSNK1D P48730 2/20 0.66
CLK2 P49760 2/20 0.66
CSNK1G2 P78368 2/20 0.66
DYRK1A Q13627 2/20 0.66
CLK4 Q9HAZ1 2/20 0.66
CSNK1G1 Q9HCP0 2/20 0.66
CCNK O75909 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3445612 0.89 CDK2 (0.67) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3445122 0.88 CDK1 (0.69) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3444679 0.88 CDK1 (0.69) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3446263 0.86 CDK1 (0.56) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3446266 0.86 CDK1 (0.56) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3445165 0.86 CDK2 (0.61) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3446493 0.85 CDK2 (0.53) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL3446820 0.84 CDK2 (0.52) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL17450135 0.83 CDK2 (1.00) CDK2CCNA2CCNA1CACNA1BCDK1
SCHEMBL13170162 0.83 CDK2 (1.00) CDK2CCNA2CCNA1CACNA1BCDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed