SCHEMBL3445532

SCHEMBL3445532

CC(Nc1nc(NC(CO)C(C)C)nc2c1nnn2C(C)C)c1ccc(O)c(O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 9/20 0.43
CDK2 P24941 12/20 0.43
CCNB2 O95067 4/20 0.43
CCNB1 P14635 4/20 0.43
CCNB3 Q8WWL7 4/20 0.43
CCNA2 P20248 10/20 0.42
CCNA1 P78396 10/20 0.42
CDK5 Q00535 10/20 0.42
DYRK1A Q13627 10/20 0.42
CDK5R1 Q15078 10/20 0.42
CCNE1 P24864 2/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
PAK4 O96013 1/20 0.40
CCNE2 O96020 1/20 0.40
ALDH1A1 P00352 1/20 0.40
TP53 P04637 1/20 0.40
CYP1A2 P05177 1/20 0.40
INSR P06213 1/20 0.40
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3445538 1.00 CDK1 (0.43) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3444788 0.90 CDK1 (0.43) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3444794 0.90 CDK1 (0.43) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3446827 0.88 CDK1 (0.41) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3446829 0.88 CDK1 (0.41) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3444502 0.83 CDK1 (0.39) CDK1CDK2CDK5CDK5R1CCNE1
SCHEMBL6016451 0.83 CDK2 (0.63) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL6016456 0.83 CDK2 (0.63) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3445124 0.79 CDK1 (0.38) CDK1CDK2CCNB2CCNB1CCNB3
SCHEMBL3445398 0.79 CDK5 (0.48) CDK1CDK2CCNB2CCNB1CCNB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed