SCHEMBL3445547

SCHEMBL3445547

CCC(CO)Nc1nc(Nc2ccc(Br)cc2)c2nnn(C)c2n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 16/20 0.52
CDK5 Q00535 15/20 0.52
CDK5R1 Q15078 15/20 0.52
CCNA2 P20248 15/20 0.52
CCNA1 P78396 14/20 0.52
DYRK1A Q13627 13/20 0.52
CDK1 P06493 2/20 0.52
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
NPC1 O15118 1/20 0.46
POLB P06746 1/20 0.46
CCNE1 P24864 2/20 0.43
CCNE2 O96020 1/20 0.43
KCNH3 Q9ULD8 1/20 0.43
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPK1 P28482 1/20 0.42
KMT2A Q03164 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
CCNT1 O60563 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3446707 0.90 CDK5 (0.52) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3446493 0.89 CDK2 (0.53) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3444438 0.89 CDK5 (0.51) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3446427 0.88 CDK5 (0.55) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3445657 0.86 CDK1 (0.68) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3445655 0.86 CDK1 (0.68) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3445806 0.82 CDK5 (0.50) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3445600 0.82 CDK5 (0.50) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3446331 0.82 CDK5 (0.68) CDK2CDK5CDK5R1CCNA2CCNA1
SCHEMBL3445379 0.81 CDK1 (0.57) CDK2CDK5CDK5R1CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed