SCHEMBL3445779

SCHEMBL3445779

CC(C)C(CO)Nc1nc(Nc2ccc(Br)cc2)c2nnn(C(C)C)c2n1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 6/20 0.69
CDK2 P24941 13/20 0.54
CDK5 Q00535 13/20 0.54
CDK5R1 Q15078 13/20 0.54
CCNA2 P20248 12/20 0.54
CCNA1 P78396 12/20 0.54
DYRK1A Q13627 12/20 0.54
EGFR P00533 1/20 0.49
CCNE2 O96020 2/20 0.48
CCNE1 P24864 2/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
CCNB2 O95067 1/20 0.48
PAK4 O96013 1/20 0.48
ALDH1A1 P00352 1/20 0.48
TP53 P04637 1/20 0.48
CYP1A2 P05177 1/20 0.48
INSR P06213 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3445781 1.00 CDK1 (0.69) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3445589 0.90 CDK1 (0.69) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3445588 0.90 CDK1 (0.69) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3446099 0.90 CCNA2 (0.56) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3446096 0.90 CCNA2 (0.56) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3445655 0.90 CDK1 (0.68) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3445657 0.90 CDK1 (0.68) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3446708 0.87 CDK1 (0.65) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3446427 0.87 CDK5 (0.55) CDK1CDK2CDK5CDK5R1CCNA2
SCHEMBL3446706 0.87 CDK1 (0.65) CDK1CDK2CDK5CDK5R1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7816350-B2 Substituted [1,2,3] triazolo[4,5-D]pyrimidines as cdk inhibitors INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2010-10-19 US claimed