Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.45 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414753 | 0.86 | GRIN1 (0.71) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL12508772 | 0.80 | KCNH2 (0.52) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL12632478 | 0.77 | GRIN2D (0.46) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL3445514 | 0.76 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL3446550 | 0.76 | GRIN2D (0.54) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL16240106 | 0.75 | GRIN2D (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL3446215 | 0.74 | CREBBP (0.50) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL3447173 | 0.73 | GRIN2D (0.58) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL3445972 | 0.73 | GRIN2D (0.57) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL3446122 | 0.72 | GRIN1 (0.73) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485363-B1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2008-10-08 | — | — | EP | claimed |
| CN-1642927-A | Cyclic amides | MERCK PATENT GMBH (DE) | 2005-07-20 | — | — | CN | claimed |
| US-20050124627-A1 | Cyclic amides | MERCK PATENT GMBH (DE) | 2005-06-09 | — | — | US | claimed |
| EP-1485363-A1 | CYCLIC AMIDES | MERCK PATENT GmbH (DE) | 2004-12-15 | — | — | EP | claimed |
| WO-2003076420-A1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2003-09-18 | — | — | WO | claimed |
| US-7816376-B2 | Cyclic amides | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-7816376-B2 | Cyclic amides | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| US-7816376-B2 | Cyclic amides | MERCK PATENT GMBH (DE) | 2010-10-19 | — | — | US | disclosed |
| EP-1485363-B1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2008-10-08 | — | — | EP | disclosed |
| CN-1642927-A | Cyclic amides | MERCK PATENT GMBH (DE) | 2005-07-20 | — | — | CN | disclosed |
| US-20050124627-A1 | Cyclic amides | MERCK PATENT GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
| EP-1485363-A1 | CYCLIC AMIDES | MERCK PATENT GmbH (DE) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003076420-A1 | CYCLIC AMIDES | MERCK PATENT GMBH (DE) | 2003-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124627-A1 | Cyclic amides | NPY1R, GRIK1, GRIK4 | GRIN2D 20/4885GRIN3B 49/4885GRIN1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.