Dapoxetine

Dapoxetine

SCHEMBL34479

CN(C)[C@@H](CCOc1cccc2ccccc12)c1ccccc1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC6A4

The experimentally established mechanism targets of Dapoxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC6A4 known ✓ P31645 1/20 0.49
HTR1B P28222 12/20 0.57
HTR1D P28221 4/20 0.53
KCNA3 P22001 1/20 0.51
KMT2A Q03164 1/20 0.49
CHRNB2 P17787 1/20 0.49
CHRNB4 P30926 1/20 0.49
CHRNA3 P32297 1/20 0.49
CHRNA4 P43681 1/20 0.49
NR2E1 Q9Y466 1/20 0.49
HRH1 P35367 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dapoxetine SCHEMBL29387056 1.00 HTR1B (0.57) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL29488428 1.00 HTR1B (0.57) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL30600097 1.00 HTR1B (0.57) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL3672581 1.00 HTR1B (0.57) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL3679561 1.00 HTR1B (0.57) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL29352095 0.99 HTR1B (0.56) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL119037 0.99 HTR1B (0.56) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL9292059 0.99 HTR1B (0.56) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL27937194 0.99 HTR1B (0.56) HTR1BHTR1DKCNA3KMT2ACHRNB2
Dapoxetine SCHEMBL27518070 0.99 HTR1B (0.56) HTR1BHTR1DKCNA3KMT2ACHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6145 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4740962-A1 PHARMACEUTICAL COMPOSITION, FORMULATION CONTAINING PHARMACEUTICAL COMPOSITION, KIT CONTAINING PHARMACEUTICAL COMPOSITION, PREPARATION METHOD FOR PHARMACEUTICAL COMPOSITION, AND USE OF PHARMACEUTICAL COMPOSITION Shanghai WD Pharmaceutical Co., Ltd (CN) 2026-05-13 EP claimed
US-12624037-B2 Method of treating agitation, aggressive behavior, and impulse control disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
US-12624036-B2 Method of treating post-traumatic stress disorder INTRA-CELLULAR THERAPIES, INC. (US) 2026-05-12 US claimed
US-12599554-B2 Pharmaceutical formulations comprising tadalafil KYDES PHARMACEUTICALS LLC (US) 2026-04-14 US claimed
US-20260077191-A1 COMBINATION THERAPY FOR THE TREATMENT OF DEPRESSION FLOW NEUROSCIENCE INC (US) 2026-03-19 US claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
US-20260034065-A1 EXTENDED RELEASE PHARMACEUTICAL FORMULATION DOUGLAS PHARMACEUTICALS LTD (NZ) 2026-02-05 US claimed
US-12514883-B2 Compositions and methods for modulating lipid and steroid metabolism THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-01-06 US claimed
US-12472146-B2 Extended release pharmaceutical formulation DOUGLAS PHARMACEUTICALS, LTD. (NZ) 2025-11-18 US claimed
US-20250339399-A1 SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM BEIJING CREATRON INSTITUTE OF PHARMACEUTICAL RES CO LTD (CN) 2025-11-06 US claimed
US-20020037828-A1 Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation VIVUS, INC. 2002-03-28 US claimed
US-20020013343-A1 Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors HEARTDRUG RESEARCH, L.L.C. 2002-01-31 US claimed
WO-2001041701-A2 THE COMBINATION OF A SEROTONIN REUPTAKE INHIBITOR AND A 5-HT2C ANTAGONIST, INVERSE AGONIST OR PARTIAL AGONIST H. LUNDBECK A/S (DK) 2001-06-14 WO claimed
WO-2001041766-A1 THE COMBINATION OF A SEROTONIN REUPTAKE INHIBITOR AND IRINDALONE H. LUNDBECK A/S (DK) 2001-06-14 WO claimed
EP-1085879-A2 MULTIBINDING AGENTS THAT MODULATE THE 5-HT TRANSPORTER Advanced Medicine, Inc. (US) 2001-03-28 EP claimed
WO-2001017521-A1 METHODS OF USING RAPID-ONSET SELECTIVE SEROTONIN REUPTAKE INHIBITORS FOR TREATING SEXUAL DYSFUNCTION ELI LILLY AND COMPANY (US) 2001-03-15 WO claimed
WO-1999063932-A9 MULTIBINDING AGENTS THAT MODULATE THE 5-HT TRANSPORTER ADVANCED MEDICINE INC (US) 2000-03-16 WO claimed
WO-2000006160-A1 TREATING DEPRESSION WITH A COMBINATION OF FLUOXETINE (PROZAC), PINDOLOL (VISKEN) AND BUSPIRONE (BUSPAR) SANOFI-SYNTHELABO (FR) 2000-02-10 WO claimed
WO-1999063932-A2 MULTIBINDING AGENTS THAT MODULATE THE 5-HT TRANSPORTER ADVANCED MEDICINE, INC. (US) 1999-12-16 WO claimed
WO-1997041878-A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed