SCHEMBL3449983

SCHEMBL3449983

Cc1ncc2n1C(=O)N(N1CCN(C(=O)CC(NC(=O)OC(C)(C)C)c3ccccc3)CC1)C2

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.44
RET P07949 1/20 0.43
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
HTT P42858 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3449900 0.86 F10 (0.41) F10KMT2A
SCHEMBL3449328 0.85 F10 (0.45) F10
SCHEMBL3449304 0.85 F10 (0.45) F10RET
SCHEMBL3449432 0.82 F10 (0.49) F10LMNAMAPTHTTKMT2A
SCHEMBL3448865 0.79 F10 (0.41) F10MAPTKMT2A
SCHEMBL3448449 0.78 F10 (0.41) F10MAPTKMT2A
SCHEMBL3448658 0.78 F10 (0.41) F10LMNAKMT2A
SCHEMBL3449802 0.78 F10 (0.41) F10LMNAKMT2A
SCHEMBL3447872 0.78 F10 (0.41) F10MAPTKMT2A
SCHEMBL3449573 0.77 F10 (0.41) F10LMNAMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7820673-B2 Urea derivative, process for producing the same, and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-10-26 US disclosed
US-20070093501-A1 Urea derivative, process for producing the same, and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-04-26 US disclosed
EP-1695961-A1 UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE Takeda Pharmaceutical Company Limited (JP) 2006-08-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070093501-A1 Urea derivative, process for producing the same, and use F2, URB2, F12 F10 22/4885RET 2112/4885LMNA 3232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.