Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 2/20 | 0.40 |
| ▸ | PTPRF | P10586 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451555 | 0.97 | MEN1 (0.44) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3453505 | 0.96 | MEN1 (0.43) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13109588 | 0.90 | MEN1 (0.47) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3453502 | 0.90 | NPC1 (0.43) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3453030 | 0.89 | MEN1 (0.47) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13109582 | 0.86 | KDM4E (0.45) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3452576 | 0.85 | KDM4E (0.44) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13109591 | 0.84 | GRM1 (0.40) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13109595 | 0.83 | KDM4E (0.45) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3453028 | 0.83 | KMT2A (0.46) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820704-B2 | Substituted heteroaryl derivatives, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261294-A1 | Substituted heteroaryl derivatives, compositions, and methods of use | MC5R, MC3R, MC4R | MEN1 1990/4885KMT2A 2090/4885L3MBTL1 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.