Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.71 |
| ▸ | CSF1R | P07333 | 1/20 | 0.71 |
| ▸ | RET | P07949 | 1/20 | 0.71 |
| ▸ | FLT4 | P35916 | 1/20 | 0.71 |
| ▸ | ABL2 | P42684 | 1/20 | 0.71 |
| ▸ | BLK | P51451 | 1/20 | 0.71 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453965 | 0.94 | AURKA (0.79) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL12846395 | 0.89 | AURKA (0.72) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL3463216 | 0.86 | AURKA (0.81) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL6522604 | 0.84 | AURKA (1.00) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL12846529 | 0.83 | AURKA (0.67) | AURKAAURKBCHEK2CSF1RRET | |
| Monoethanolamine SCHEMBL3453633 | 0.83 | AURKA (0.67) | AURKAAURKBCHEK2RETFLT4 | |
| SCHEMBL3455072 | 0.83 | AURKA (0.69) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL3454241 | 0.82 | AURKA (0.67) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL6525760 | 0.81 | AURKA (0.88) | AURKAAURKBCHEK2CSF1RRET | |
| SCHEMBL6525630 | 0.81 | AURKA (0.88) | AURKAAURKBCHEK2CSF1RRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | claimed |
| US-20110053906-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-03-03 | — | — | US | claimed |
| EP-2254889-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | Merck Patent GmbH (DE) | 2010-12-01 | — | — | EP | claimed |
| WO-2009108670-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2009-09-03 | — | — | WO | claimed |
| US-8735584-B2 | Protein kinase inhibitors and use thereof | MERCK PATENT GMBH (DE) | 2014-05-27 | — | — | US | disclosed |
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | disclosed |
| US-20110053906-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053906-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP4K2, MAP3K20, MAP4K1 | AURKA 538/4885AURKB 487/4885CHEK2 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.