Nicorandil

Nicorandil

SCHEMBL34547

O=C(NCCO[N+](=O)[O-])c1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 1.00
MEN1 O00255 4/20 1.00
CYP2C9 P11712 3/20 1.00
CYP2C19 P33261 3/20 1.00
ALOX15 P16050 1/20 1.00
HSD17B10 Q99714 1/20 1.00
MAPT P10636 3/20 0.64
RXFP1 Q9HBX9 1/20 0.64
CYP3A4 P08684 2/20 0.64
CYP1A2 P05177 1/20 0.64
USP2 O75604 1/20 0.60
ALDH1A1 P00352 4/20 0.59
SMN1; SMN2 Q16637 4/20 0.59
NPC1 O15118 2/20 0.59
RAB9A P51151 2/20 0.59
PKM P14618 1/20 0.57
THRB P10828 1/20 0.56
LMNA P02545 3/20 0.55
POLB P06746 1/20 0.54
EPHX2 P34913 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nicorandil SCHEMBL5051667 1.00 KMT2A (1.00) KMT2AMEN1CYP2C9CYP2C19ALOX15
Nicorandil SCHEMBL29512234 1.00 KMT2A (1.00) KMT2AMEN1CYP2C9CYP2C19ALOX15
Nicorandil SCHEMBL10766084 0.99 KMT2A (0.97) KMT2AMEN1CYP2C9CYP2C19ALOX15
Nicorandil SCHEMBL9559453 0.96 KMT2A (0.93) KMT2AMEN1CYP2C9CYP2C19ALOX15
Nicorandil SCHEMBL2319411 0.93 KMT2A (0.86) KMT2AMEN1CYP2C9CYP2C19ALOX15
SCHEMBL3864549 0.92 KMT2A (0.85) KMT2AMEN1CYP2C9CYP2C19ALOX15
SCHEMBL8260990 0.91 KMT2A (0.83) KMT2AMEN1CYP2C9CYP2C19ALOX15
SCHEMBL12276739 0.89 KMT2A (0.80) KMT2AMEN1CYP2C9CYP2C19ALOX15
SCHEMBL12103276 0.89 KMT2A (0.80) KMT2AMEN1CYP2C9CYP2C19ALOX15
Hydrochloric Acid SCHEMBL28748599 0.87 KMT2A (0.76) KMT2AMEN1CYP2C9CYP2C19ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 9924 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122065019-A Oil well sensor spatial relationship modeling method based on centrality guide map convolution 中北大学 2026-05-19 CN claimed
CN-224262872-U Nicorandil test sampling device 湖北世科药业有限公司 2026-05-19 CN claimed
CN-122031423-A Composition containing nicorandil multi-piece structure for stepwise gentle sustained and controlled release drug delivery 迈迪欣生物医药科技(西安)有限公司 2026-05-15 CN claimed
CN-122036995-A Self-cascade reinforced immunotherapeutic hydrogel based on hydroxybutyl chitosan material, and preparation method and application thereof 沈阳药科大学 2026-05-15 CN claimed
CN-122031142-A Targeted drug delivery device for improving coronary microcirculation disturbance 雄安宣武医院 2026-05-15 CN claimed
EP-4736841-A1 A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT IQ medical GmbH (DE) 2026-05-06 EP claimed
EP-3338813-B2 MULTI-LAYER WOUND CARE PRODUCT WITH PERFORATED RELEASE LAYER BSN MEDICAL GMBH (DE) 2026-04-15 EP claimed
US-20260076961-A1 COMBINATION TREATMENTS Celex Oncology Innovations Limited (GB) 2026-03-19 US claimed
EP-3558399-B2 MULTI-LAYER WOUND CARE PRODUCT WITH PERFORATED RELEASE LAYER BSN MEDICAL GMBH (DE) 2026-01-14 EP claimed
WO-2025230907-A1 A CXCR4 ANTAGONIST, A STATS ACTIVATOR, AND/OR AN AGENT THAT INCREASES NITRIC OXIDE CONTENT FOR USE IN METHODS OF IMPROVING NERVE REGENERATION THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2025-11-06 WO claimed
EP-0259309-A1 METHOD OF TREATMENT AND PREVENTION OF CEREBRAL VASOSPASMS MEDICAL COLLEGE OF WISCONSIN RESEARCH FOUNDATION, INC. (US) 1988-03-16 EP claimed
WO-1987005508-A1 METHOD OF TREATMENT AND PREVENTION OF CEREBRAL VASOSPASMS MEDICAL COLLEGE OF WISCONSIN RESEARCH FOUNDATION, (US) 1987-09-24 WO claimed
EP-0236679-A1 Nicorandil-containing preparation for injection Chugai Seiyaku Kabushiki Kaisha (JP) 1987-09-16 EP claimed
CN-87100285-A Produce the method for stable nicorandil preparation 1987-08-19 CN claimed
EP-0230932-A2 Method for production of stable nicorandil preparation Chugai Seiyaku Kabushiki Kaisha (JP) 1987-08-05 EP claimed
EP-0223811-A1 USE OF NICORANDIL OR PINACIDIL FOR THE TREATMENT OF PERIPHERAL VASCULAR DISEASE BEECHAM GROUP PLC (GB) 1987-06-03 EP claimed
EP-0218148-A1 Slow-release pharmaceutical composition Chugai Seiyaku Kabushiki Kaisha (JP) 1987-04-15 EP claimed
WO-1986006960-A2 USE OF NICORANDIL OR PINACIDIL FOR THE TREATMENT OF PERIPHERAL VASCULAR DISEASE BEECHAM GROUP P.L.C. (GB) 1986-12-04 WO claimed
CN-85109190-A Produce the method for stable nicorandil preparation 1986-07-16 CN claimed
EP-0185347-A2 Method for production of stable nicorandil preparation Chugai Seiyaku Kabushiki Kaisha (JP) 1986-06-25 EP claimed