Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | AURKA | O14965 | 2/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.57 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482391 | 0.87 | EGFR (0.55) | EGFRAURKAMAPK8CAMKK2PIK3CG | |
| SCHEMBL14569550 | 0.83 | EGFR (0.73) | EGFRAURKAMAPK8CAMKK2PIK3CG | |
| SCHEMBL20004385 | 0.82 | EGFR (0.71) | EGFRAURKAMAPK8CAMKK2PIK3CG | |
| SCHEMBL14676415 | 0.81 | PLAU (0.48) | EGFRAURKAMAPK8CAMKK2CCNB2 | |
| SCHEMBL4491188 | 0.80 | HTT (0.62) | SMN1; SMN2KDRCCNB2CDK1CCNB1 | |
| SCHEMBL29430401 | 0.80 | HTT (0.62) | SMN1; SMN2KDRCCNB2CDK1CCNB1 | |
| SCHEMBL4920783 | 0.78 | EGFR (0.66) | EGFRAURKAMAPK8CAMKK2PIK3CG | |
| SCHEMBL11813903 | 0.78 | MAPT (0.83) | EGFRAURKAMAPTALDH1A1KDM4E | |
| SCHEMBL12801671 | 0.78 | CDK5 (0.66) | EGFRAURKAMAPK8CAMKK2PIK3CG | |
| SCHEMBL20355106 | 0.78 | HTT (0.60) | EGFRMAPTALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612149-A1 | PYRIDO[2,3-D]PYRIMIDIN-2-AMINE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| EP-2154967-A1 | PYRIMIDINE DERIVATIVES | Hutchison Medipharma Enterprises Limited (BS) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008128231-A1 | PYRIMIDINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2008-10-23 | — | — | WO | disclosed |