Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456217 | 0.92 | CRBN (0.39) | CRBNDDB1TRPV1MAPTALDH1A1 | |
| SCHEMBL5067941 | 0.89 | TRPV1 (0.38) | CRBNDDB1TRPV1MAPTALDH1A1 | |
| SCHEMBL1984304 | 0.74 | TRPV1 (0.57) | CRBNDDB1TRPV1MAPTALDH1A1 | |
| SCHEMBL29301634 | 0.72 | MAPT (0.61) | MAPTWNT3ASMN1; SMN2RAB9ACYP1A2 | |
| SCHEMBL9909938 | 0.71 | CNR2 (0.43) | CRBNDDB1TRPV1MAPTALDH1A1 | |
| SCHEMBL9909937 | 0.69 | NAMPT (0.49) | TRPV1MAPTALDH1A1WNT3ABCL2 | |
| SCHEMBL3455945 | 0.68 | KDR (0.44) | MAPTALDH1A1KDM4E | |
| SCHEMBL1734048 | 0.66 | P4HTM (0.54) | KDM4ENAMPTL3MBTL1 | |
| SCHEMBL29929054 | 0.66 | P4HTM (0.54) | KDM4ENAMPTL3MBTL1 | |
| SCHEMBL9909935 | 0.65 | NAMPT (0.42) | MAPTALDH1A1KDM4EWNT3ABCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| EP-1646632-A2 | SUBSTITUTED TETRAHYDRO-1 I H /I -PYRAZOLO 3,4-C|PYRIDINES, COMPOSITIONS CONTAINING SAME AND USE | Aventis Pharma S.A. (FR) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005007653-A2 | SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINES, COMPOSITIONS CONTAINING SAME AND USE | AVENTIS PHARMA S.A. (FR) | 2005-01-27 | — | — | WO | disclosed |