Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455817 | 0.87 | NPC1 (0.38) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3455946 | 0.86 | NPC1 (0.38) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL14031952 | 0.86 | HPSE (0.41) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3456150 | 0.86 | NPC1 (0.37) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3455320 | 0.86 | TRPV1 (0.38) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3456885 | 0.84 | NPC1 (0.40) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3457585 | 0.83 | HPSE (0.39) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3455651 | 0.83 | HPSE (0.39) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL14032049 | 0.83 | GPBAR1 (0.42) | KDM4ENPC1RAB9AALDH1A1HPGD | |
| SCHEMBL3456645 | 0.82 | EP300 (0.39) | KDM4ENPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251340-A1 | Substituted tetrahydro-1h-pyrazolo[3,4-c] pyridines, compositions containing same and use thereof | Aventis Pharma S.A. (FR) | 2010-11-17 | — | — | EP | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |
| US-7435820-B2 | Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use | AVENTIS PHARMA S.A. (FR) | 2008-10-14 | — | — | US | disclosed |