Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 1.00 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 1.00 |
| ▸ | CTSD | P07339 | 9/20 | 0.74 |
| ▸ | APP | P05067 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14258096 | 0.94 | BACE1 (0.88) | BACE1BACE2CTSDAPP | |
| Hydrochloric Acid SCHEMBL4880385 | 0.93 | BACE1 (0.86) | BACE1BACE2CTSDAPP | |
| SCHEMBL4894769 | 0.91 | BACE1 (0.84) | BACE1BACE2CTSDAPP | |
| SCHEMBL4889163 | 0.90 | BACE1 (0.82) | BACE1BACE2CTSDAPP | |
| SCHEMBL4883718 | 0.87 | BACE1 (0.76) | BACE1BACE2CTSDAPP | |
| SCHEMBL4890205 | 0.87 | BACE1 (0.79) | BACE1BACE2CTSDAPP | |
| SCHEMBL3457365 | 0.86 | BACE1 (1.00) | BACE1BACE2CTSDAPP | |
| SCHEMBL4884550 | 0.86 | BACE1 (0.88) | BACE1BACE2CTSDAPP | |
| SCHEMBL8221614 | 0.85 | BACE1 (0.74) | BACE1BACE2CTSDAPP | |
| SCHEMBL3456304 | 0.85 | BACE1 (1.00) | BACE1BACE2CTSDAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264036-A1 | Amino-imidazolones for the inhibition of beta-secretase | Wyeth LLC (Formerly Known As Wyeth) (US) | 2010-12-22 | — | — | EP | claimed |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-10-08 | — | — | US | claimed |
| US-7563796-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2009-07-21 | — | — | US | claimed |
| EP-1836208-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | Wyeth Incoporated (US) | 2007-09-26 | — | — | EP | claimed |
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | WYETH (US) | 2006-07-20 | — | — | US | claimed |
| WO-2006076284-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | WYETH (US) | 2006-07-20 | — | — | WO | claimed |
| EP-2264036-A1 | Amino-imidazolones for the inhibition of beta-secretase | Wyeth LLC (Formerly Known As Wyeth) (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-10-08 | — | — | US | disclosed |
| US-7563796-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2009-07-21 | — | — | US | disclosed |
| EP-1836208-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | Wyeth Incoporated (US) | 2007-09-26 | — | — | EP | disclosed |
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| WO-2006076284-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | WYETH (US) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160828-A1 | Amino-imidazolones for the inhibition of beta-secretase | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885CTSD 249/4885 |
| US-20090253716-A1 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | BACE1 1/4885BACE2 2/4885CTSD 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.