Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.55 |
| ▸ | ACVRL1 | P37023 | 12/20 | 0.55 |
| ▸ | RET | P07949 | 5/20 | 0.55 |
| ▸ | ROS1 | P08922 | 5/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 5/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3465417 | 0.94 | NTRK1 (0.59) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL13692318 | 0.94 | NTRK1 (0.59) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL13692266 | 0.92 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL3459663 | 0.92 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL13692264 | 0.92 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL13692530 | 0.91 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL13692361 | 0.88 | NTRK1 (0.56) | NTRK1ACVRL1RETROS1NTRK3 | |
| Trifluoroacetic Acid SCHEMBL14719368 | 0.86 | NTRK1 (0.56) | NTRK1ACVRL1RETROS1NTRK3 | |
| Trifluoroacetic Acid SCHEMBL14718959 | 0.86 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1NTRK3 | |
| Trifluoroacetic Acid SCHEMBL3469072 | 0.86 | NTRK1 (0.55) | NTRK1ACVRL1RETROS1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262807-A1 | NOVEL TYROSINE KINASE INHIBITORS | ChemBridge Corporation (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009117097-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |