Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12946842 | 0.94 | SMN1; SMN2 (0.47) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL964364 | 0.88 | KMT2A (0.45) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL3459382 | 0.87 | HPGD (0.44) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL964828 | 0.87 | HPGD (0.44) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL3460495 | 0.87 | KDM4E (0.38) | KMT2ASMN1; SMN2MEN1LMNAALDH1A1 | |
| SCHEMBL10180464 | 0.87 | KMT2A (0.47) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL10181157 | 0.87 | KMT2A (0.47) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL3460097 | 0.86 | MAPK8 (0.40) | KMT2AMEN1ALDH1A1POLBNPSR1 | |
| SCHEMBL10180841 | 0.85 | KMT2A (0.43) | HPGDKMT2ASMN1; SMN2PKMMEN1 | |
| SCHEMBL966008 | 0.85 | KMT2A (0.42) | HPGDKMT2ASMN1; SMN2PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |