Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.55 |
| ▸ | ATR | Q13535 | 7/20 | 0.55 |
| ▸ | PRKDC | P78527 | 2/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | STAMBP | O95630 | 1/20 | 0.49 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | KLK1 | P06870 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462065 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3461445 | 0.92 | AURKA (0.59) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3461030 | 0.91 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3461795 | 0.90 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3460881 | 0.89 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3461280 | 0.89 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CGATRPIK3CB | |
| SCHEMBL3461603 | 0.89 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3459920 | 0.89 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3459849 | 0.89 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CGATRPRKDC | |
| SCHEMBL3460038 | 0.89 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CGATRPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | claimed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | claimed |
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | PIK3CD 375/4885PIK3CA 463/4885PIK3CG 477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.