Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461565 | 0.94 | KMT2A (0.43) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL964955 | 0.83 | MEN1 (0.48) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL10181157 | 0.79 | KMT2A (0.47) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL10180464 | 0.79 | KMT2A (0.47) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL966640 | 0.78 | KMT2A (0.45) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL964953 | 0.76 | MEN1 (0.51) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL10180897 | 0.73 | HPGD (0.42) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL12946902 | 0.73 | MEN1 (0.48) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL12947108 | 0.72 | MEN1 (0.51) | KMT2AMEN1PKMHPGDLMNA | |
| SCHEMBL10180462 | 0.72 | SMN1; SMN2 (0.49) | KMT2AMEN1PKMHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | claimed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |