Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8740549 | 1.00 | NAMPT (0.65) | NAMPTMEN1ALDH1A1KMT2AHTT | |
| SCHEMBL8092135 | 1.00 | NAMPT (0.65) | NAMPTMEN1ALDH1A1KMT2AHTT | |
| SCHEMBL1665424 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL15364885 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL192420 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL18141994 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL3328510 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL17923298 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL5802535 | 0.85 | NAMPT (0.52) | NAMPTMEN1ALDH1A1KMT2AP2RX7 | |
| SCHEMBL3106753 | 0.84 | NAMPT (0.58) | NAMPTMEN1ALDH1A1KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |
| US-20060211709-A1 | Protein kinase modulators and methods of use | EXELIXIS, INC. | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211709-A1 | Protein kinase modulators and methods of use | GRK2, MAP4K2, MAPKAPK2 | NAMPT 2400/4885MEN1 4800/4885ALDH1A1 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.