Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27805818 | 0.91 | KMT2A (0.77) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL2450877 | 0.85 | KMT2A (0.69) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL653632 | 0.80 | KMT2A (0.67) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL28358852 | 0.80 | KMT2A (0.67) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL395690 | 0.80 | KMT2A (0.67) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL11816392 | 0.80 | KMT2A (0.61) | KMT2AHTTSMN1; SMN2GLANPC1 | |
| SCHEMBL29212534 | 0.78 | CSNK1A1 (0.59) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL7193170 | 0.78 | KMT2A (0.63) | KMT2AHTTSMN1; SMN2GLANPC1 | |
| Biphenyl SCHEMBL27718930 | 0.76 | CSNK1A1 (0.49) | KMT2ACSNK1A1TYRO3DYRK1BHTT | |
| SCHEMBL34651 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795448-B2 | Imidazoyl-benzamide anti-cancer agents | CYTOKINETICS, INCORPORATED (US) | 2010-09-14 | — | — | US | disclosed |
| US-7582668-B2 | Imidazoyl-benzamide anti-cancer agents | CYTOKINETICS, INCORPORATED (US) | 2009-09-01 | — | — | US | disclosed |