Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.71 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.71 |
| ▸ | TRAP1 | Q12931 | 4/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.69 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469974 | 0.93 | HSP90AA1 (0.82) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL4475861 | 0.92 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL29581212 | 0.91 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL12990283 | 0.91 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3463753 | 0.90 | HSP90AB1 (0.72) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL4895777 | 0.89 | HSP90AB1 (0.87) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL4479672 | 0.89 | HSP90AA1 (0.81) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL14067080 | 0.89 | HSP90AB1 (0.87) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL8153232 | 0.89 | HSP90AA1 (0.85) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL3465181 | 0.87 | HSP90AB1 (0.76) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100240656-A1 | COMPOUNDS AS HSP90 INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2010-09-23 | — | — | US | disclosed |
| EP-2183221-A1 | NEW COMPOUNDS AS HSP90 INHIBITORS | Crystax Pharmaceuticals S.L. (ES) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009007399-A1 | NEW COMPOUNDS AS HSP90 INHIBITORS | CRYSTAX PHARMACEUTICALS, S.L. (ES) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240656-A1 | COMPOUNDS AS HSP90 INHIBITORS | HSP90AB1, HSP90AB2P, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885HDAC3 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.