Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466296 | 0.89 | POLB (0.48) | ABCG2EGFRBRAFPSEN1PSEN2 | |
| SCHEMBL3467043 | 0.88 | ABCG2 (0.54) | MC4RABCG2EGFRBRAFFYN | |
| SCHEMBL3466230 | 0.87 | MAPT (0.47) | MC4RABCG2EGFRBRAFPSEN1 | |
| SCHEMBL3470499 | 0.86 | FYN (0.62) | ABCG2EGFRBRAFPSEN1PSEN2 | |
| SCHEMBL3466346 | 0.83 | TTK (0.45) | ABCG2EGFRFYNCTSCTTK | |
| SCHEMBL3466303 | 0.82 | GAA (0.53) | MC4RABCG2BRAFFYNTTK | |
| SCHEMBL3466944 | 0.82 | DYRK1A (0.44) | ABCG2BRAFFYNCTSCTTK | |
| SCHEMBL3465711 | 0.81 | SYK (0.45) | ABCG2BRAFFYNTTK | |
| SCHEMBL3469213 | 0.80 | FYN (0.55) | MC4RABCG2BRAFFYNTTK | |
| SCHEMBL3466340 | 0.80 | CLK4 (0.55) | FYNPDGFRBTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |