Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 14/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 17/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 17/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3466880 | 1.00 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2CYP2D6TSHR | |
| SCHEMBL3466080 | 0.87 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2CYP2D6TSHR | |
| SCHEMBL3466077 | 0.87 | SLC6A4 (0.62) | SLC6A4SLC6A3SLC6A2CYP2D6TSHR | |
| SCHEMBL13345115 | 0.79 | SLC6A4 (0.57) | SLC6A4SLC6A3SLC6A2CYP2D6TSHR | |
| SCHEMBL3465934 | 0.77 | SLC6A4 (0.70) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3465937 | 0.77 | SLC6A4 (0.70) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3466877 | 0.76 | SLC6A4 (0.77) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3466881 | 0.76 | SLC6A4 (0.77) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL13345071 | 0.75 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL3465568 | 0.75 | SLC6A4 (0.63) | SLC6A4SLC6A3SLC6A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071575-A1 | QUATERNARY PIPERIDINE DERIVATIVES AND USES THEREOF | ASTRAZENECA AB (SE) | 2010-06-24 | — | — | WO | disclosed |