Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.41 |
| ▸ | ATM | Q13315 | 7/20 | 0.41 |
| ▸ | PRKDC | P78527 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3055887 | 0.95 | ATR (0.41) | ATRATMPRKDCGSK3B | |
| SCHEMBL15684385 | 0.85 | ATR (0.44) | ATRATMPRKDCGSK3B | |
| SCHEMBL667416 | 0.84 | ATR (0.40) | ATRATMPRKDCGSK3B | |
| SCHEMBL667542 | 0.82 | ATR (0.41) | ATRATMPRKDCGSK3B | |
| SCHEMBL19102162 | 0.78 | ATR (0.38) | ATRATMPRKDCGSK3B | |
| SCHEMBL667206 | 0.74 | ATR (0.39) | ATRATMPRKDCGSK3B | |
| SCHEMBL14829434 | 0.74 | ATR (0.42) | ATRATMPRKDCGSK3B | |
| SCHEMBL10141979 | 0.73 | ATR (0.41) | ATRATMPRKDCGSK3B | |
| SCHEMBL15684386 | 0.71 | ATR (0.43) | ATRATMPRKDCGSK3B | |
| SCHEMBL29243957 | 0.71 | ATR (0.45) | ATRATMPRKDCGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071837-A1 | PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-24 | — | — | WO | disclosed |