Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | GRK5 | P34947 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467350 | 1.00 | NTRK1 (0.56) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL3467529 | 1.00 | NTRK1 (0.56) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL1520549 | 0.86 | NTRK1 (0.69) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL26425931 | 0.85 | MEN1 (0.61) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL23600366 | 0.80 | CGAS (0.51) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL29764637 | 0.80 | CGAS (0.51) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL23600353 | 0.80 | CGAS (0.51) | NTRK1RETPRKD3ABL1DAPK3 | |
| SCHEMBL23600364 | 0.77 | KDM4E (0.44) | KDRFLT3MEN1KMT2AMAPT | |
| SCHEMBL15045784 | 0.77 | GSK3B (0.44) | KDRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL23600355 | 0.77 | CHEK1 (0.58) | LRRK2MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074746-A1 | METHODS OF USE FOR OPSIN BINDING LIGANDS | BIKAM PHARMACEUTICALS, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-5627207-A | CANCER | FARMITALIA CARLO ERBA S R L (IT) | 1997-05-06 | — | — | US | disclosed |
| US-5488057-A | ENZYME INHIBITORS AND ANTICARCINOGENIC AGENTS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1996-01-30 | — | — | US | disclosed |
| EP-0662473-A1 | 2-Oxindole derivatives as tyrosine kinase inhibitors | PHARMACIA S.p.A. (IT) | 1995-07-12 | — | — | EP | disclosed |
| US-5374652-A | Substituted naphthylmethylene- or tetrahydronaphthylmethylene-derivatives of 2-oxoindole | FARMITALIA CARLO ERBA S R L (IT) | 1994-12-20 | — | — | US | disclosed |
| WO-1991013055-A2 | NEW ARYL- AND HETEROARYLETHENYLENE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-09-05 | — | — | WO | disclosed |
| US-4110536-A | ANTIARRHYTHMIA | MILES LABORATORIES, INC. (US) | 1978-08-29 | — | — | US | disclosed |