Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 11/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466056 | 0.90 | TTK (0.57) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3469213 | 0.88 | FYN (0.55) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3466661 | 0.86 | BRAF (0.52) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL5416134 | 0.86 | FYN (0.54) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3467351 | 0.84 | FYN (0.55) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3466123 | 0.83 | BRAF (0.53) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3466122 | 0.83 | TTK (0.55) | DYRK3CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL3470453 | 0.82 | TTK (0.64) | BRAFTTKFYN | |
| SCHEMBL14767444 | 0.82 | TTK (0.54) | BRAFTTKFYNIDO1ABCG2 | |
| SCHEMBL3466505 | 0.81 | FYN (0.58) | DYRK3CCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |