Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.60 |
| ▸ | EGFR | P00533 | 7/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.60 |
| ▸ | RAF1 | P04049 | 5/20 | 0.60 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.51 |
| ▸ | STK4 | Q13043 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28769852 | 0.90 | MAP2K1 (0.67) | MAP2K1EGFRERBB2RAF1MAP3K8 | |
| SCHEMBL15320481 | 0.90 | MAP2K1 (0.77) | MAP2K1EGFRERBB2RAF1MAP3K8 | |
| SCHEMBL27707326 | 0.88 | EGFR (0.53) | MAP2K1EGFRERBB2RAF1MAP3K8 | |
| SCHEMBL1893034 | 0.88 | EGFR (0.65) | EGFRERBB2MAP3K8PDE4B | |
| SCHEMBL27728172 | 0.88 | EGFR (0.55) | MAP2K1EGFRERBB2RAF1MAP3K8 | |
| SCHEMBL1897881 | 0.87 | EGFR (0.64) | MAP2K1EGFRERBB2RAF1MAP3K8 | |
| SCHEMBL1892933 | 0.87 | EGFR (0.60) | EGFRERBB2MAP3K8PDE4B | |
| SCHEMBL1893339 | 0.87 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL6381746 | 0.87 | EGFR (0.66) | EGFRERBB2MAP3K8PDE4B | |
| SCHEMBL9911596 | 0.87 | EGFR (0.60) | EGFRERBB2MAP3K8PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848581-B | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2021-08-10 | — | — | CN | claimed |
| CN-111848581-A | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2020-10-30 | — | — | CN | claimed |
| CN-111848581-B | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2021-08-10 | — | — | CN | disclosed |
| CN-111848581-B | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2021-08-10 | — | — | CN | disclosed |
| CN-111848581-B | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2021-08-10 | — | — | CN | disclosed |
| CN-111848581-A | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2020-10-30 | — | — | CN | disclosed |
| CN-111848581-A | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2020-10-30 | — | — | CN | disclosed |
| CN-111848581-A | Preparation method of 3-cyano-4-anilino-6-aminoquinoline derivative | 昆明学院 | 2020-10-30 | — | — | CN | disclosed |
| WO-2010076764-A1 | IRREVERSIBLE EGFR INHIBITOR COMPOUNDS WITH ANTIPROLIFERATIVE ACTIVITY | UNIVERSITA' DEGLI STUDI DI PARMA (IT) | 2010-07-08 | — | — | WO | disclosed |