Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 10/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054108 | 0.84 | SPPL2A (0.66) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3469433 | 0.77 | SPPL2A (0.52) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1057302 | 0.72 | SPPL2A (0.66) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1058776 | 0.67 | SPPL2A (0.73) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5780154 | 0.67 | SPPL2A (0.75) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1059437 | 0.67 | SPPL2A (0.58) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1056509 | 0.67 | SPPL2A (0.75) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5781096 | 0.65 | SPPL2A (0.63) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1057407 | 0.62 | SPPL2A (0.85) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14338808 | 0.62 | SPPL2A (0.76) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264032-B1 | HIV PROTEASE INHIBITING SULFONAMIDES | ABBVIE INC (US) | 2013-08-07 | — | — | EP | disclosed |
| EP-2264032-A2 | Hiv protease inhibiting sulfonamides | Abbott Laboratories (US) | 2010-12-22 | — | — | EP | disclosed |