Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.64 |
| ▸ | INSR | P06213 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | NPM1 | P06748 | 3/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519705 | 0.92 | JAK2 (0.75) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL521546 | 0.85 | JAK2 (0.70) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520022 | 0.82 | JAK2 (0.60) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520790 | 0.81 | ALK (0.73) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL522459 | 0.81 | ALK (0.73) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519058 | 0.80 | JAK2 (0.73) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL2510881 | 0.80 | JAK2 (0.71) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL2521959 | 0.79 | JAK2 (1.00) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL519194 | 0.78 | JAK2 (0.55) | JAK2ALKINSRCYP3A4NPM1 | |
| SCHEMBL520566 | 0.77 | JAK2 (0.81) | JAK2ALKINSRCYP3A4NPM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |