Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.47 |
| ▸ | ACVRL1 | P37023 | 11/20 | 0.47 |
| ▸ | RET | P07949 | 5/20 | 0.47 |
| ▸ | ROS1 | P08922 | 5/20 | 0.47 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3469078 | 0.99 | NTRK1 (0.47) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL773090 | 0.81 | NTRK1 (0.64) | NTRK1ACVRL1RETROS1NTRK3 | |
| Hydrochloric Acid SCHEMBL768310 | 0.81 | NTRK1 (0.63) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL3461158 | 0.80 | NTRK1 (0.57) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL768143 | 0.79 | NTRK1 (0.54) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL13692321 | 0.78 | NTRK1 (0.48) | NTRK1ACVRL1RETROS1NTRK3 | |
| Hydrochloric Acid SCHEMBL768584 | 0.78 | NTRK1 (0.53) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL767789 | 0.78 | NTRK1 (0.59) | NTRK1ACVRL1RETROS1NTRK3 | |
| Hydrochloric Acid SCHEMBL3466822 | 0.78 | NTRK1 (0.47) | NTRK1ACVRL1RETROS1NTRK3 | |
| SCHEMBL438635 | 0.77 | NTRK1 (0.60) | NTRK1ACVRL1RETROS1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262807-A1 | NOVEL TYROSINE KINASE INHIBITORS | ChemBridge Corporation (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009117097-A1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE CORPORATION (US) | 2009-09-24 | — | — | WO | disclosed |