Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 16/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 16/20 | 0.80 |
| ▸ | MAPT | P10636 | 14/20 | 0.80 |
| ▸ | RECQL | P46063 | 14/20 | 0.80 |
| ▸ | POLB | P06746 | 10/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.80 |
| ▸ | HPGD | P15428 | 5/20 | 0.80 |
| ▸ | APEX1 | P27695 | 3/20 | 0.80 |
| ▸ | THRB | P10828 | 2/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.80 |
| ▸ | NSD2 | O96028 | 2/20 | 0.80 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.80 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.80 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.80 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | ALPL | P05186 | 1/20 | 0.73 |
| ▸ | ALPI | P09923 | 1/20 | 0.73 |
| ▸ | ALPG | P10696 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712984 | 1.00 | MEN1 (0.80) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL3471120 | 1.00 | MEN1 (0.80) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14712893 | 0.89 | MEN1 (0.74) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL16542997 | 0.86 | DUSP3 (1.00) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14712947 | 0.84 | MEN1 (1.00) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14713067 | 0.84 | MEN1 (0.81) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14712869 | 0.81 | BCL2A1 (0.61) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14712995 | 0.81 | BCL2A1 (0.61) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14712966 | 0.78 | KMT2A (0.51) | MEN1KMT2AMAPTRECQLPOLB | |
| SCHEMBL14712882 | 0.78 | MEN1 (0.51) | MEN1KMT2AMAPTRECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9211296-B2 | Therapeutic compounds for blocking DNA synthesis of POX viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-15 | — | — | US | disclosed |
| US-20130338117-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-12-19 | — | — | US | disclosed |
| US-8524719-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120322770-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-12-20 | — | — | US | disclosed |
| US-8278342-B2 | Therapeutic compounds for blocking DNA synthesis of pox viruses | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100035887-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322770-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | TPX2, POLB, POLM | MEN1 4101/4885KMT2A 3300/4885MAPT 4220/4885 |
| US-20100035887-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | TPX2, POLB, POLM | MEN1 4101/4885KMT2A 3300/4885MAPT 4220/4885 |
| US-20130338117-A1 | THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES | TPX2, POLB, POLM | MEN1 4101/4885KMT2A 3300/4885MAPT 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.