Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521256 | 0.77 | JAK2 (0.43) | JAK2PTK2CCNT1CDK9 | |
| SCHEMBL520212 | 0.77 | JAK2 (0.50) | JAK2PTK2 | |
| SCHEMBL522076 | 0.75 | JAK2 (0.41) | JAK2PTK2CNR2 | |
| SCHEMBL522000 | 0.74 | JAK2 (0.49) | JAK2PTK2 | |
| SCHEMBL16530345 | 0.70 | JAK2 (0.48) | JAK2PTK2 | |
| SCHEMBL522100 | 0.69 | JAK2 (0.49) | JAK2PTK2 | |
| SCHEMBL521137 | 0.68 | JAK2 (0.48) | JAK2PTK2CDK1 | |
| SCHEMBL521169 | 0.67 | JAK2 (0.45) | JAK2PTK2 | |
| SCHEMBL521685 | 0.65 | JAK2 (0.42) | JAK2PTK2CCNT1CDK9 | |
| SCHEMBL521134 | 0.65 | KCNH2 (0.44) | JAK2PTK2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | claimed |