Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.67 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.67 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | KDM1A | O60341 | 1/20 | 0.67 |
| ▸ | F3 | P13726 | 1/20 | 0.67 |
| ▸ | NAMPT | P43490 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471941 | 1.00 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL3471896 | 1.00 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL8094983 | 0.91 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL8089914 | 0.85 | HDAC1 (0.49) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL13110753 | 0.85 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL13110741 | 0.84 | HDAC1 (0.62) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL8349026 | 0.84 | HDAC1 (0.63) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL13110745 | 0.83 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL13110984 | 0.83 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC11HDAC8 | |
| SCHEMBL13110986 | 0.83 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267779-A1 | Novel Compounds and Methods of Using Them | SYNDAX PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267779-A1 | Novel Compounds and Methods of Using Them | SYNDAX PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267779-A1 | Novel Compounds and Methods of Using Them | SYNDAX PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | US | disclosed |
| WO-2009015237-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267779-A1 | Novel Compounds and Methods of Using Them | HDAC1, HDAC3, HDAC6 | HDAC1 1/4885HDAC3 2/4885HDAC2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.