Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.59 |
| ▸ | PFKFB3 | Q16875 | 7/20 | 0.52 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15690858 | 0.83 | PTGES2 (0.60) | GAAL3MBTL1PTGES2PFKFB3PFKFB4 | |
| SCHEMBL3473396 | 0.83 | PTGES2 (0.60) | GAAL3MBTL1PTGES2PFKFB3PFKFB4 | |
| SCHEMBL15690849 | 0.82 | PTGES2 (0.63) | GAAL3MBTL1PTGES2PFKFB3MAPT | |
| SCHEMBL15480577 | 0.82 | GAA (0.63) | GAAL3MBTL1PTGES2PFKFB3PFKFB4 | |
| SCHEMBL3473369 | 0.81 | PTGES2 (0.58) | GAAL3MBTL1PTGES2PFKFB3PFKFB4 | |
| SCHEMBL3472654 | 0.81 | PTGES2 (0.64) | GAAL3MBTL1PTGES2PFKFB3PFKFB4 | |
| SCHEMBL3472410 | 0.81 | PTGES2 (0.64) | GAAL3MBTL1PTGES2PFKFB3PFKFB4 | |
| SCHEMBL3473873 | 0.80 | PTGES2 (0.63) | GAAL3MBTL1PTGES2PFKFB3MAPT | |
| SCHEMBL3474065 | 0.79 | PTGES2 (0.64) | GAAL3MBTL1PTGES2PFKFB3MAPT | |
| SCHEMBL12334074 | 0.78 | GAA (0.61) | GAAL3MBTL1PTGES2PFKFB3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | GAA 2305/4885L3MBTL1 2172/4885PTGES2 1035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.