Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.67 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 2/20 | 0.48 |
| ▸ | LYN | P07948 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | FRK | P42685 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936550 | 0.83 | RAF1 (0.60) | RAF1KDRBRAFPDGFRA | |
| SCHEMBL1846064 | 0.82 | RAF1 (1.00) | RAF1KDRABL1RETEPHA2 | |
| SCHEMBL1506319 | 0.81 | RAF1 (0.81) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL618105 | 0.80 | RAF1 (1.00) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL1506318 | 0.76 | RAF1 (0.81) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL1660255 | 0.75 | RAF1 (0.79) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL937287 | 0.75 | RAF1 (1.00) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL5566298 | 0.74 | RAF1 (0.84) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL5564956 | 0.74 | RAF1 (0.84) | RAF1GSK3BKDRABL1RET | |
| SCHEMBL14453613 | 0.74 | RAF1 (0.77) | RAF1GSK3BKDRABL1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838541-B2 | Aryl ureas with angiogenesis inhibiting activity | BAYER HEALTHCARE, LLC (US) | 2010-11-23 | — | — | US | claimed |