Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 15/20 | 0.52 |
| ▸ | TDO2 | P48775 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476566 | 0.89 | GRM2 (0.52) | GRM2TDO2PDE4A | |
| SCHEMBL3476639 | 0.88 | GRM2 (0.54) | GRM2TDO2PDE4AHRH1 | |
| SCHEMBL3474795 | 0.85 | GRM2 (0.62) | GRM2TDO2 | |
| SCHEMBL3477243 | 0.84 | GRM2 (0.54) | GRM2TDO2 | |
| SCHEMBL3474734 | 0.84 | GRM2 (0.52) | GRM2 | |
| SCHEMBL3475474 | 0.83 | GRM2 (0.48) | GRM2 | |
| SCHEMBL3475341 | 0.82 | GRM2 (0.49) | GRM2TDO2 | |
| SCHEMBL3475484 | 0.81 | GRM2 (0.54) | GRM2TDO2 | |
| SCHEMBL7822106 | 0.81 | GRM2 (0.56) | GRM2TDO2 | |
| SCHEMBL3475658 | 0.80 | GRM2 (0.46) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |