Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.41 |
| ▸ | CNR2 | P34972 | 6/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3474286 | 0.90 | RET (0.43) | GRM2CNR2CNR1AURKAAXL | |
| SCHEMBL3474262 | 0.86 | GRM2 (0.43) | GRM2CNR2CNR1AURKAAXL | |
| SCHEMBL3476720 | 0.86 | CNR2 (0.52) | GRM2CNR2CNR1 | |
| SCHEMBL3474206 | 0.85 | RET (0.46) | RET | |
| SCHEMBL3475599 | 0.81 | GRM2 (0.46) | GRM2 | |
| SCHEMBL3475688 | 0.80 | GRM2 (0.49) | GRM2 | |
| SCHEMBL3476498 | 0.80 | GRM2 (0.51) | GRM2 | |
| SCHEMBL3475824 | 0.79 | GRM2 (0.49) | GRM2KDR | |
| SCHEMBL3477455 | 0.79 | GRM2 (0.48) | GRM2 | |
| SCHEMBL3476219 | 0.78 | GRM2 (0.49) | GRM2CNR2AXLMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |