Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCND3 | P30281 | 5/20 | 0.83 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.83 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.83 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.83 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.83 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.83 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.83 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.83 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.83 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.83 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.83 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.83 |
| ▸ | CDK2 | P24941 | 14/20 | 0.75 |
| ▸ | CCNE2 | O96020 | 13/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.75 |
| ▸ | CDK4 | P11802 | 7/20 | 0.69 |
| ▸ | CCND1 | P24385 | 7/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.69 |
| ▸ | CDK1 | P06493 | 6/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477501 | 0.98 | HDAC3 (0.83) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3467498 | 0.97 | HDAC3 (0.84) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3467490 | 0.94 | CDK2 (0.78) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4203348 | 0.91 | HDAC3 (1.00) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3466814 | 0.90 | CCND3 (0.86) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4207837 | 0.90 | CCND3 (0.83) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3467568 | 0.90 | CDK2 (0.74) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18231939 | 0.89 | CCND3 (0.85) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4211024 | 0.89 | HDAC3 (1.00) | CCND3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9950338 | 0.89 | HDAC3 (0.82) | CCND3HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563741-B2 | CDK inhibitors containing a zinc binding moiety | CURIS, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120165335-A1 | CDK INHIBITORS | CURIS, INC. | 2012-06-28 | — | — | US | disclosed |
| WO-2010075542-A1 | CDK INHIBITORS | CURIS, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
| US-20090093507-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2009-04-09 | — | — | US | disclosed |
| WO-2009036016-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093507-A1 | CDK INHIBITORS CONTAINING A ZINC BINDING MOIETY | CDK3, CDKL1, CDKL3 | CCND3 85/4885HDAC3 36/4885HDAC4 22/4885 |
| US-20120165335-A1 | CDK INHIBITORS | CDK3, CDK6, CDKL1 | CCND3 47/4885HDAC3 560/4885HDAC4 246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.