Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476323 | 0.91 | JAK1 (0.44) | HRH4JAK2JAK1JAK3CHEK2 | |
| SCHEMBL3477661 | 0.87 | HRH4 (0.41) | HRH4JAK2JAK1JAK3CHEK2 | |
| SCHEMBL3475556 | 0.85 | JAK2 (0.40) | JAK2JAK1JAK3CHEK2DRD3 | |
| SCHEMBL3476731 | 0.84 | HRH4 (0.49) | HRH4JAK2JAK1 | |
| SCHEMBL3475384 | 0.83 | HRH4 (0.46) | HRH4JAK2JAK1 | |
| SCHEMBL3475781 | 0.83 | HRH4 (0.41) | HRH4CHEK2 | |
| SCHEMBL3476347 | 0.83 | HRH4 (0.46) | HRH4 | |
| SCHEMBL3476818 | 0.78 | HRH4 (0.46) | HRH4JAK2JAK1 | |
| SCHEMBL3476308 | 0.76 | HRH4 (0.63) | HRH4JAK2JAK1JAK3 | |
| SCHEMBL3476897 | 0.75 | HRH4 (0.68) | HRH4JAK2JAK1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004188-B1 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-01 | — | — | EP | claimed |