Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477455 | 0.86 | GRM2 (0.48) | GRM2 | |
| SCHEMBL3473809 | 0.82 | GRM2 (0.49) | GRM2CYP11B2CYP11B1 | |
| SCHEMBL3475599 | 0.82 | GRM2 (0.46) | GRM2 | |
| SCHEMBL3475600 | 0.81 | GRM2 (0.53) | GRM2CYP11B2CYP11B1 | |
| SCHEMBL3476571 | 0.80 | GRM2 (0.53) | GRM2CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL3476091 | 0.78 | GRM2 (0.40) | GRM2 | |
| SCHEMBL3475603 | 0.77 | GRM2 (0.54) | GRM2 | |
| SCHEMBL3475688 | 0.77 | GRM2 (0.49) | GRM2 | |
| SCHEMBL3476498 | 0.76 | GRM2 (0.51) | GRM2 | |
| SCHEMBL3475409 | 0.76 | GRM2 (0.53) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |