SCHEMBL3477023

SCHEMBL3477023

Cc1c(F)ccc2[nH]c(-c3ccnc(NCCCCC4CCN(C)CC4)c3)nc12.Cc1cc(Cl)cc2[nH]c(-c3ccnc(NCCCCC4CCN(C)CC4)c3)nc12

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 19/20 0.57
KCNH2 Q12809 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3477458 0.93 HRH4 (0.64) HRH4KCNH2
SCHEMBL3477252 0.93 HRH4 (0.53) HRH4KCNH2
SCHEMBL3477813 0.85 HRH4 (0.63) HRH4KCNH2
SCHEMBL3477393 0.83 HRH4 (0.63) HRH4
SCHEMBL3476972 0.81 HRH4 (0.56) HRH4KCNH2
SCHEMBL602545 0.80 HRH4 (0.55) HRH4
SCHEMBL604280 0.80 HRH4 (0.74) HRH4KCNH2
SCHEMBL3477674 0.80 HRH4 (0.69) HRH4
SCHEMBL3477290 0.79 HRH4 (0.55) HRH4KCNH2
SCHEMBL3475762 0.79 HRH4 (0.56) HRH4KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2004188-B1 BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR JANSSEN PHARMACEUTICA NV (BE) 2010-09-01 EP claimed