SCHEMBL3477065

SCHEMBL3477065

Cc1ccccc1C12CNCC1C2

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 5/20 0.56
SLC6A4 P31645 5/20 0.56
SLC6A3 Q01959 5/20 0.56
KCNH2 Q12809 2/20 0.56
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL18741903 0.98 SLC6A2 (0.54) SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL22918145 0.81 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3KCNH2CYP1A2
SCHEMBL4185356 0.81 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3KCNH2CYP1A2
Hydrochloric Acid SCHEMBL4184047 0.80 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL22755235 0.79 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3KCNH2CYP1A2
SCHEMBL4711875 0.79 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3KCNH2CYP1A2
Hydrochloric Acid SCHEMBL11076402 0.78 SLC6A2 (0.56) SLC6A2SLC6A4SLC6A3KCNH2CYP1A2
SCHEMBL4187080 0.77 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL4185566 0.77 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL31284256 0.77 SLC6A2 (0.55) SLC6A2SLC6A4SLC6A3KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1874298-A4 METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3,1,0]HEXANES DOV PHARMACEUTICAL INC (US) 2009-08-05 EP claimed
EP-1904059-A2 METHOD FOR TREATING NERVOUS SYSTEM DISORDERS AND CONDITIONS Wyeth a Corporation of the State of Delaware (US) 2008-04-02 EP claimed
EP-1874298-A2 METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3,1,0]HEXANES DOV Pharmaceutical Inc. (US) 2008-01-09 EP claimed
WO-2007013936-A2 METHOD FOR TREATING NERVOUS SYSTEM DISORDERS AND CONDITIONS WYETH (US) 2007-02-01 WO claimed
US-20070021488-A1 Method for treating nervous system disorders and conditions WYETH (US) 2007-01-25 US claimed
WO-2006096810-A2 METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3.1.0] HEXANES DOV PHARMACEUTICAL, INC. (US) 2006-09-14 WO claimed
EP-4384165-A1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS Janssen Pharmaceutica NV (BE) 2024-06-19 EP disclosed
WO-2023019094-A1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS JANSSEN PHARMACEUTICA NV (BE) 2023-02-16 WO disclosed
EP-4103557-A1 MONOACYLGLYCEROL LIPASE MODULATORS Janssen Pharmaceutica NV (BE) 2022-12-21 EP disclosed
EP-2167083-A2 NOVEL 1- HETEROARYL-3-AZABICYCLOÝ3.1.0¨HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS DOV Pharmaceutical, Inc. (US) 2010-03-31 EP disclosed
EP-1874298-A4 METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3,1,0]HEXANES DOV PHARMACEUTICAL INC (US) 2009-08-05 EP disclosed
WO-2008153937-A2 NOVEL 1- HETEROARYL-3-AZABICYCLO[3.1.0]HEXANES, METHODS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS DOV PHARMACEUTICAL, INC. (US) 2008-12-18 WO disclosed
EP-1915148-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS DOV Pharmaceutical, Inc. (US) 2008-04-30 EP disclosed
EP-1904059-A2 METHOD FOR TREATING NERVOUS SYSTEM DISORDERS AND CONDITIONS Wyeth a Corporation of the State of Delaware (US) 2008-04-02 EP disclosed
EP-1874298-A2 METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3,1,0]HEXANES DOV Pharmaceutical Inc. (US) 2008-01-09 EP disclosed
WO-2007014264-A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS DOV PHARMACEUTICAL, INC. (US) 2007-02-01 WO disclosed
WO-2007013936-A2 METHOD FOR TREATING NERVOUS SYSTEM DISORDERS AND CONDITIONS WYETH (US) 2007-02-01 WO disclosed
US-20070021488-A1 Method for treating nervous system disorders and conditions WYETH (US) 2007-01-25 US disclosed
WO-2006096810-A2 METHODS AND COMPOSITIONS FOR PRODUCTION, FORMULATION AND USE OF 1-ARYL-3-AZABICYCLO[3.1.0] HEXANES DOV PHARMACEUTICAL, INC. (US) 2006-09-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070021488-A1 Method for treating nervous system disorders and conditions AVPR1B, AVPR2, AVPR1A SLC6A2 33/4885SLC6A4 145/4885SLC6A3 100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.