Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 12/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475824 | 0.84 | GRM2 (0.49) | GRM2 | |
| SCHEMBL3475688 | 0.82 | GRM2 (0.49) | GRM2CDK9 | |
| SCHEMBL3476498 | 0.82 | GRM2 (0.51) | GRM2 | |
| SCHEMBL3475404 | 0.82 | GRM2 (0.43) | GRM2 | |
| SCHEMBL3476219 | 0.80 | GRM2 (0.49) | GRM2MERTK | |
| SCHEMBL7819601 | 0.80 | GRM2 (0.49) | GRM2 | |
| SCHEMBL7823314 | 0.80 | GRM2 (0.39) | GRM2GRIN2BCDK9 | |
| SCHEMBL3475089 | 0.79 | GRM2 (0.48) | GRM2 | |
| SCHEMBL3475599 | 0.79 | GRM2 (0.46) | GRM2 | |
| SCHEMBL3475606 | 0.78 | GRM2 (0.49) | GRM2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |