Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 8/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475607 | 0.82 | HRH4 (0.54) | HRH4DHODHGSK3BRHEB | |
| SCHEMBL3477250 | 0.75 | HRH4 (0.40) | HRH4KCNH2CARM1DHODHGSK3B | |
| SCHEMBL3477813 | 0.75 | HRH4 (0.63) | HRH4KCNH2CARM1DHODHSSTR2 | |
| SCHEMBL3477939 | 0.72 | HRH4 (0.53) | HRH4GSK3B | |
| SCHEMBL605436 | 0.71 | HRH4 (0.55) | HRH4KCNH2CARM1DHODHSSTR2 | |
| SCHEMBL3476758 | 0.71 | HRH4 (0.50) | HRH4KCNH2GSK3B | |
| SCHEMBL3476926 | 0.71 | HRH4 (0.55) | HRH4KCNH2CARM1DHODHSSTR2 | |
| Hydrochloric Acid SCHEMBL4480586 | 0.70 | HRH4 (0.55) | HRH4KCNH2CARM1DHODHSSTR2 | |
| SCHEMBL3476927 | 0.70 | HRH4 (0.52) | HRH4KCNH2CARM1DHODHSSTR2 | |
| Hydrochloric Acid SCHEMBL3478395 | 0.69 | HRH4 (0.51) | HRH4KCNH2CARM1DHODHSSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004188-B1 | BENZOIMIDAZOL-2-YL PYRIDINES AS MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2010-09-01 | — | — | EP | disclosed |