Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 12/20 | 0.63 |
| ▸ | MAPK9 | P45984 | 12/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.63 |
| ▸ | GSK3B | P49841 | 4/20 | 0.63 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.63 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.63 |
| ▸ | CSNK1G1 | Q9HCP0 | 4/20 | 0.63 |
| ▸ | CSNK1G3 | Q9Y6M4 | 4/20 | 0.63 |
| ▸ | CDK2 | P24941 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | GSK3A | P49840 | 3/20 | 0.63 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.63 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.63 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818595 | 0.93 | MAPK8 (0.72) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2745509 | 0.89 | MAPK9 (0.58) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL3818827 | 0.87 | CDK2 (0.55) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL3812911 | 0.85 | MAPK8 (0.69) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| Hydrochloric Acid SCHEMBL2745924 | 0.84 | MAPK8 (0.68) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL3813008 | 0.84 | MAPK9 (0.71) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL3477389 | 0.82 | MAPK8 (0.66) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL12023650 | 0.82 | MAPK8 (0.51) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2745543 | 0.82 | MAPK8 (0.51) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2745547 | 0.82 | MAPK8 (0.51) | MAPK8MAPK9PRKD3MAP4K4CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258704-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ArQule, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |