Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110999 | 0.90 | PIK3CD (0.66) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2673673 | 0.85 | PIK3CD (0.74) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2110753 | 0.85 | PIK3CD (0.74) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2674525 | 0.84 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2674582 | 0.83 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2674259 | 0.83 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2674638 | 0.81 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2674970 | 0.81 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2675481 | 0.81 | PIK3CD (0.64) | PIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL2675604 | 0.81 | PIK3CD (0.68) | PIK3CDPIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136491-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-02 | — | — | WO | disclosed |