⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455921 | 0.67 | — | — | |
| SCHEMBL4316592 | 0.65 | — | — | |
| SCHEMBL1654819 | 0.65 | — | — | |
| SCHEMBL1650923 | 0.65 | — | — | |
| SCHEMBL1064651 | 0.65 | — | — | |
| SCHEMBL380104 | 0.65 | — | — | |
| SCHEMBL350137 | 0.65 | — | — | |
| SCHEMBL6003467 | 0.62 | — | — | |
| SCHEMBL21559904 | 0.61 | — | — | |
| SCHEMBL10324975 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 285 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11932658-B2 | Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as PAR4 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-03-19 | — | — | US | claimed |
| CN-117209453-A | Preparation and application of levocetirizine hydrochloride intermediate | 迪嘉药业集团股份有限公司 | 2023-12-12 | — | — | CN | claimed |
| CN-115666517-A | Treatment of inflammatory bowel disease | 兹杜斯生命科学有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-113195483-A | Novel oxadiazole compound | PI工业有限公司 | 2021-07-30 | — | — | CN | claimed |
| CN-109796383-B | 1-thiophenyl-N-acetyl-2-naphthylamine and its derivative and synthesis method | 湘潭大学 | 2020-09-18 | — | — | CN | claimed |
| EP-3484894-B1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-19 | — | — | EP | claimed |
| EP-3484894-A1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | Bristol-Myers Squibb Company (US) | 2019-05-22 | — | — | EP | claimed |
| US-10183948-B2 | N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists | OGEDA SA (BE) | 2019-01-22 | — | — | US | claimed |
| WO-2018013776-A1 | TRICYCLIC HETEROARYL-SUBSTITUTED QUINOLINE AND AZAQUINOLINE COMPOUNDS AS PAR4 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-01-18 | — | — | WO | claimed |
| US-9840508-B2 | N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders | OGED SA (BE) | 2017-12-12 | — | — | US | claimed |
| EP-0956287-A1 | 3-ARYL-2-(1-SUBSTITUTED-4-PIPERIDINYL)-1(1-DI)OXO-3H-BENZO D]-ISOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF NEUROTRANSMITTER FUNCTION | HOECHST MARION ROUSSEL, INC. (US) | 1999-11-17 | — | — | EP | claimed |
| WO-1998028295-A1 | 3-ARYL-2-(1-SUBSTITUTED-4-PIPERIDINYL)-1(1-DI)OXO-3H-BENZO[D]-ISOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF NEUROTRANSMITTER FUNCTION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-02 | — | — | WO | claimed |
| EP-0590489-B1 | New cyclopentanperhydrophenanthren-17beta-(hydroxy or alkoxy)-17alpha-(aryl or heterocyclyl)-3beta-derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1996-12-11 | — | — | EP | claimed |
| EP-0590489-A2 | New cyclopentanperhydrophenanthren-17beta-(hydroxy or alkoxy)-17alpha-(aryl or heterocyclyl)-3beta-derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-04-06 | — | — | EP | claimed |
| EP-0125901-B1 | FUNGICIDAL ANILINE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-02-08 | — | — | EP | claimed |
| EP-0109418-A4 | GONADOLIBERIN DERIVATIVES, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL AND VETERINARY COMPOSITIONS THEREOF. | RICHTER GEDEON VEGYESZET (HU) | 1987-11-12 | — | — | EP | claimed |
| EP-0127899-A1 | Cyclic pentapeptides displaying somatostatin antagonism and method of treatment of mammals therewith | The Administrators of The Tulane University Educational Fund (US) | 1984-12-12 | — | — | EP | claimed |
| EP-0017738-B1 | AN INSECTICIDAL AND MITICIDAL COMPOSITION WHICH CONTAINS A CARBAMATE AND AN ORGANIC PHOSPHORUS COMPOUND, AND A METHOD OF CONTROLLING INSECTS AND MITES THEREWITH | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-08-08 | — | — | EP | claimed |
| EP-0109418-A1 | GONADOLIBERIN DERIVATIVES, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL AND VETERINARY COMPOSITIONS THEREOF | REANAL FINOMVEGYSZERGYAR (HU) | 1984-05-30 | — | — | EP | claimed |
| WO-1983004250-A1 | GONADOLIBERIN DERIVATIVES, PROCESS FOR THE PREPARATION AND PHARMACEUTICAL AND VETERINARY COMPOSITIONS THEREOF | RICHTER GEDEON VEGYÉSZETI GYÁR R.T. (HU) | 1983-12-08 | — | — | WO | claimed |