Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4254495 | 1.00 | BACE1 (0.47) | BACE1MCHR1SLC2A1 | |
| SCHEMBL3479525 | 0.94 | BACE1 (0.49) | BACE1MCHR1 | |
| Trifluoroacetic Acid SCHEMBL3479500 | 0.90 | BACE1 (0.58) | BACE1 | |
| Trifluoroacetic Acid SCHEMBL3479506 | 0.90 | BACE1 (0.58) | BACE1 | |
| SCHEMBL3479509 | 0.84 | BACE1 (0.64) | BACE1 | |
| SCHEMBL3479630 | 0.84 | BACE1 (0.64) | BACE1 | |
| SCHEMBL3479463 | 0.84 | BACE1 (0.64) | BACE1 | |
| Trifluoroacetic Acid SCHEMBL3479502 | 0.83 | BACE1 (0.40) | BACE1MCHR1SLC2A1 | |
| SCHEMBL3479550 | 0.81 | BACE1 (0.54) | BACE1MCHR1 | |
| Trifluoroacetic Acid SCHEMBL3479447 | 0.81 | BACE1 (0.48) | BACE1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298342-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease | MERCK & CO., INC. (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298342-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease | BACE1, APP, PSEN1 | BACE1 1/4885MCHR1 4417/4885SLC2A1 4551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.