Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479663 | 0.96 | BACE1 (0.37) | BACE1MEN1KMT2AMCHR1CACNA1F | |
| Trifluoroacetic Acid SCHEMBL3479427 | 0.86 | NR1H2 (0.35) | BACE1MEN1KMT2AMCHR1CACNA1F | |
| SCHEMBL3479561 | 0.83 | BACE1 (0.37) | BACE1MEN1KMT2AMCHR1CACNA1F | |
| Trifluoroacetic Acid SCHEMBL3479385 | 0.82 | MEN1 (0.40) | BACE1MEN1KMT2ACACNA1FCHRM2 | |
| Trifluoroacetic Acid SCHEMBL3479548 | 0.81 | GPR6 (0.34) | BACE1MEN1KMT2ACACNA1FCHRM2 | |
| SCHEMBL3479554 | 0.80 | JAK2 (0.37) | BACE1MCHR1CACNA1FCHRM2ADRB1 | |
| SCHEMBL13031027 | 0.80 | ACKR3 (0.39) | BACE1MCHR1KCNH2FAAH | |
| Trifluoroacetic Acid SCHEMBL3479896 | 0.78 | CHRM2 (0.33) | BACE1MEN1KMT2AMCHR1CACNA1F | |
| SCHEMBL3479620 | 0.77 | CACNA1F (0.41) | BACE1MEN1KMT2ACACNA1FCHRM2 | |
| Trifluoroacetic Acid SCHEMBL3479647 | 0.75 | MCHR1 (0.39) | BACE1MCHR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298342-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease | MERCK & CO., INC. (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298342-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease | BACE1, APP, PSEN1 | BACE1 1/4885MEN1 1565/4885KMT2A 4150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.